William R. Frazier was born ABT 1820. He was the son of William Frazier and Lucretia Harmon Draber.
William R. Frazier's wife was Nancy Hays. Their 8 known children were Harmon Hays Frazier, Dorothy Jane Frazier, Hanna M. Frazier, John Wm Frazier, Harriet Ann Frazier, Arabelle Lucretia Frazier, Mary Louisa Frazier and Susan Rebecca Frazier.